J.R. Miller emphasizes the transformative power of prayer, illustrating how Jesus was transfigured while praying, and how this transfiguration can manifest in the lives of believers. He explains that prayer not only brings us closer to God but also changes our hearts, faces, and circumstances, allowing us to reflect Christ's glory. Miller highlights that through prayer, cares, sorrows, and duties are transfigured into blessings, teaching us valuable lessons and deepening our character. He encourages believers to embrace prayer as a means of surrendering to God's will, which ultimately leads to spiritual transformation. The sermon concludes with the assurance that prayer brings divine grace and blessings into our lives, changing our weaknesses into strengths.