Chuck Smith emphasizes that God's purposes are unchangeable and will ultimately prevail, regardless of the moral decay seen in society today. He discusses how God has established specific purposes for nations and individuals, and while these purposes may be delayed, they will not be disannulled. Smith highlights the importance of prayer, noting that it does not change God's plans but opens the door for His will to be accomplished. He reassures that God's loving purpose for each person is for their highest good, urging individuals to align their will with God's. The sermon calls for recognition of God's sovereignty and the necessity of seeking His will in our lives.