K.P. Yohannan emphasizes the importance of praying with a thankful heart, recognizing that God answers prayers not based on our merit but through His grace. He encourages believers to express gratitude for past blessings, present provisions, and future promises, while also maintaining healthy relationships by forgiving others. Specificity in prayer is vital; we should clearly articulate our needs without dictating how God should respond. Additionally, he highlights the necessity of praying with a burden, as true breakthroughs often come from a heart deeply moved by the Holy Spirit. This approach fosters a confident and effective prayer life.