John Gill preaches on the sufferings of the Messiah, emphasizing the prophetic significance of Psalms 22 and Isaiah 53. He explains how these scriptures foreshadowed the trials and tribulations that Jesus would endure, including betrayal, rejection, and crucifixion, all of which were fulfilled in Christ's life. Gill highlights that the New Testament writers consistently referenced these prophecies to affirm Jesus as the Messiah, who suffered not for his own sins but for the transgressions of humanity. The sermon underscores the importance of recognizing these prophecies as integral to understanding the nature and purpose of Christ's suffering and the glory that follows.