John Wesley emphasizes that those who are in Christ Jesus and walk according to the Spirit are free from condemnation. He explains that true believers, justified by faith, are no longer under the law's condemnation due to their past, present, or even inward sins, as they are empowered by the Holy Spirit to live righteously. Wesley clarifies that while believers may struggle with sin, their sincere efforts to walk in the Spirit ensure they are not condemned by God or their own conscience. He encourages believers to trust in God's grace and to continue striving for holiness, knowing that their faith in Christ secures their standing before God. The sermon concludes with practical inferences on living a life led by the Spirit, free from fear and condemnation.