David Wilkerson emphasizes the vital role of believers in the ministry of refreshing one another, as illustrated in Acts 27 and 2 Timothy. He highlights the example of Onesiphorus, who sought out Paul in his suffering, demonstrating unconditional love and support. Wilkerson argues that true healing comes from a refreshed spirit, which can combat depression and mental anguish. He also draws parallels to David's experience with Jonathan, who provided encouragement during a time of distress. The sermon calls for believers to actively seek out and uplift those who are hurting, showcasing the power of community in spiritual healing.