A.W. Tozer emphasizes that God initiates the desire within us to seek Him, and it is our responsibility to cooperate with His work in our lives. He explains that the urge to escape spiritual stagnation is evidence of God's action in our hearts, and we should not let doubts or false humility hinder our progress. Tozer encourages believers to recognize that if God has placed a desire in us to change, He will also provide the means to achieve that change when we earnestly seek His help. The sermon calls for an active partnership with God, dismissing any thoughts that suggest we are unworthy of His assistance.