Harry Ironside emphasizes that while God's creation and goodness should lead humanity to repentance, many remain unresponsive, drifting further into sin despite experiencing His blessings. He illustrates that calamities and suffering often fail to produce true repentance, as seen in biblical accounts and contemporary society, where fear and hardship can harden hearts instead. Ironside warns against the false hope of post-mortem repentance, asserting that character is solidified in life, and those who die unrepentant remain so eternally. He calls for a return to preaching that emphasizes the seriousness of sin and the necessity of repentance, urging believers to help others recognize their need for salvation before it is too late.