A.W. Tozer emphasizes the heavy responsibility of preaching, highlighting that true shepherds must address the specific needs of their congregation rather than delivering generic messages. He critiques the approach of indiscriminately applying biblical teachings without considering the unique circumstances of the listeners, likening it to giving the same medicine to all patients. Tozer illustrates this by referencing the New Testament epistles and the prophetic writings, which were crafted in response to particular situations. He underscores the importance of the Holy Spirit's guidance in preaching, as demonstrated by Nathan's confrontation of David, which led to genuine repentance. The sermon calls for preachers to be attentive to the specific needs of their flock to effectively minister God's Word.