Zac Poonen emphasizes that God desires to dwell in homes characterized by peace, humility, and holiness. He explains that a true sanctuary is not just a physical structure but a place where God's glory is present, which is often absent in homes filled with conflict and material concerns. Poonen highlights the importance of being contrite and lowly in spirit, focusing on personal shortcomings rather than the failures of others. He also stresses that holiness should permeate every aspect of life, not just during religious activities, but in daily actions and interactions. Ultimately, a home should be a sanctuary where Jesus feels at home, reflecting His presence in all that is done there.