Andrew Bonar reflects on the lack of belief from Jesus' own brethren, highlighting the emotional burden this placed on Christ during His ministry. He emphasizes the importance of family support in faith and the guilt that comes from not acknowledging the truth of Christ, especially for those who have unsaved family members. Bonar notes that after Christ's resurrection, there was a significant change in the hearts of His brethren, leading to their eventual faith and service in the early church. He encourages believers to pray fervently for their unsaved loved ones, as transformation can happen even in the most unlikely circumstances. The sermon serves as a reminder to turn to Christ without delay, as the opportunity for change is often in this lifetime.