David Wilkerson emphasizes how the Holy Ghost brought comfort to Paul during his darkest times through the arrival of Titus. Paul, feeling cast down and weary, experienced a profound uplift as Titus shared encouraging news from the Corinthian church, which had responded positively to Paul's previous instructions. This fellowship and the refreshing spirit of Titus filled Paul with joy, demonstrating that God often uses people to bring comfort and renewal to one another. Wilkerson reflects on the importance of community and support in overcoming struggles, highlighting that even in tribulation, God provides what we need for the battle.