John Gill Bible Commentary

Lord, why castest thou off my soul?.... Here begins his prayer, which he determined to present early in the morning, and consists of expostulations, and a representation of his distressed case: this shows that he was under soul desertion, and which was what so greatly afflicted him; imagining that his soul was cast off by the Lord, and had no more share in his affection, and was no more under his care, and in his sight: such expostulations of the saints, the church, and people of God, in a like case, are elsewhere met with, Psa 43:3 and may be applied to Christ, when his soul was exceeding sorrowful unto death, and was made an offering for sin; and particularly when he was forsaken by his Father: the Targum is, "why hast thou forsaken my soul?'' and rises the word "sabachtha", which Christ did when on the cross, Mat 27:46, the Septuagint version is, "wherefore, O Lord, dost thou reject my prayers?'' "why hidest thou thy face from me?" which is a denial of sensible communion, a withdrawing the influences and communications of divine grace for a time; and which sometimes is the case of the best of men, as Job, David, and others; and is very grieving and distressing to them; and, for the most part, is on account of sin; it is sin which separates between God and his people, and causes him to hide his face from them, or not grant them his gracious presence: this was the case of Christ, who knew no sin, while he was suffering for the sins of his people; see Psa 69:17 compared with Mat 27:46.