J.C. Ryle emphasizes the critical question of 'Where are your sins?' urging listeners to confront their sinfulness and the necessity of cleansing through Christ's blood. He asserts that all humans are inherently sinful and cannot cleanse their own sins, highlighting the importance of recognizing one's need for forgiveness. Ryle passionately explains that the blood of Jesus is the only remedy for sin, and faith in Him is essential for salvation. He calls for a genuine response to this question, encouraging individuals to seek Christ for cleansing and to understand the eternal implications of their sins.