J.R. Miller emphasizes the contrast between wholesome and unwholesome living, illustrating how wholesome individuals positively influence their surroundings with cheerfulness, love, and activity, while unwholesome individuals often succumb to negativity and morbidness. He explains that true wholesomeness encompasses not just physical health but also mental and spiritual well-being, urging believers to cultivate a heart filled with God's love and to actively engage in helping others. Miller highlights that a wholesome life is marked by generosity, forgiveness, and a focus on the good in others, ultimately reflecting Christ's love. He concludes that a life lived in accordance with God's Word is a source of inspiration and blessing to the world.