John Gill emphasizes the importance of understanding the times and the responsibilities of the people of God, drawing from the example of the tribe of Issachar, who were wise and knowledgeable about what Israel should do. He encourages believers to be watchful and active in their faith, performing good works that align with God's will, and to remain steadfast in the face of challenges and temptations. Gill highlights the necessity of prayer, community, and adherence to the teachings of Christ, especially in times of spiritual decline. He calls for a proactive approach to faith, urging believers to strengthen their resolve and prepare for the coming of the Lord. Ultimately, he reassures that despite the darkness, a glorious morning of redemption is promised for those who remain faithful.

T. Austin-Sparks addresses the current crisis in Christianity, emphasizing the need for spiritual discernment and understanding of the times in which we live. He draws from Scripture, particularly the men of Issachar who understood the times and knew what Israel ought to do, highlighting the importance of recognizing God's movements and the changes in divine economy. Sparks stresses that true knowledge comes from experience with God rather than mere information, and that the coming of Christ represents a significant divide in history, necessitating a shift in our understanding and practice of faith. He calls for believers to embrace this spiritual crisis and to seek a deeper revelation of Christ within themselves, moving beyond historical and theological knowledge to a transformative spiritual experience. The sermon concludes with a prayer for divine understanding and guidance in navigating these tumultuous times.