David Wilkerson addresses the common desire to escape during crises, emphasizing that while many Christians may feel overwhelmed by life's burdens, true refuge is found in God. He highlights the biblical concept of cities of refuge for those in distress and reminds believers that the Lord is a strong tower where they can find safety. Wilkerson encourages the faithful to turn to Jesus in times of trouble, as He offers rest and salvation. The sermon underscores the importance of prayer and standing firm in faith, even when circumstances are challenging.