Watchman Nee explores the contrasting lives of Isaac and Jacob, emphasizing that while Isaac's life was peaceful, Jacob's journey was fraught with struggles and divine discipline. He illustrates that God's work in Jacob's life was necessary to transform his natural strength into reliance on God, culminating in a pivotal moment of wrestling with God at Peniel. This encounter led to Jacob's ultimate surrender and a change in identity, highlighting that true strength comes from weakness and dependence on God. Nee encourages believers to recognize their own 'Jacob' nature and the need for God's transformative touch in their lives. The sermon concludes with the reminder that those who are touched by God may not fully understand the change, but the evidence will be evident in their lives.