E.M. Bounds emphasizes the immense possibilities of prayer, illustrating its necessity and power through biblical examples, particularly the prayers of Solomon, Samuel, and Jacob. He asserts that prayer is essential to human existence, rooted in our needs and instincts, and that it serves as a universal remedy for all troubles. Bounds highlights that God is always ready to respond to heartfelt prayers, regardless of the circumstances, and that true prayer can bring about miraculous changes. He encourages believers to recognize the boundless potential of prayer, which is linked to God's infinite power and integrity. The sermon calls for a deeper commitment to prayer, showcasing its transformative effects on individuals and nations.