Chuck Smith discusses Nebuchadnezzar's troubling dream in Daniel 2:45, emphasizing the significance of the great image representing various kingdoms, culminating in the coming kingdom of Christ. He explains the dream's details, including the head of gold and the feet of iron and clay, and connects it to future prophetic visions in Daniel 7. Smith highlights the anticipated revival of the Roman Empire, the rise of the anti-Christ, and the eventual return of Jesus with His saints, urging listeners to recognize the signs of the times and the sovereignty of God over history.