David Wilkerson emphasizes that the Christian life is a race where the true prize is the knowledge of Jesus Christ, rather than worldly success or acclaim. He warns against competing with one another for prosperity, which corrupts the race and diminishes Christ's role in our lives. Wilkerson reflects on the humility and perseverance of early Christians who endured suffering for the sake of Christ, asserting that the ultimate reward is worth any sacrifice. He encourages believers to renounce worldly ambitions and focus on obtaining more of Jesus, leading to true contentment and happiness. The sermon calls for a refocusing of priorities to seek the true prize in Christ.