David Wilkerson emphasizes the profound truth that Jesus, despite calling us to take up our cross, experienced the weight of His own cross to the point of exhaustion. He highlights that Jesus did not carry His cross alone, as Simon of Cyrene was compelled to help Him, illustrating that we too cannot bear our burdens solely by our own strength. This sermon reveals that Jesus understands our struggles and weaknesses, reminding us that the true temptation lies in attempting to carry our crosses without relying on His grace. Ultimately, Wilkerson encourages believers to recognize their need for divine assistance in their trials, as Jesus' grace is sufficient for our weaknesses.