John Wesley emphasizes the essence of spiritual worship as a deep communion with the true God, who is both the Creator and the sustainer of life. He explains that true happiness and eternal life are found in knowing and loving God, as revealed through Jesus Christ. Wesley highlights that this relationship is not merely about outward actions or beliefs but is rooted in a transformative experience of God's love and presence in our lives. He encourages believers to seek their fulfillment in God alone, as all other pursuits are ultimately unfulfilling. The sermon concludes with a call to maintain this relationship through prayer and spiritual vigilance.