Mike Bickle emphasizes the prophetic significance of Isaiah 11-12, highlighting the coming reign of Jesus as a glorious King who will restore creation and unify Israel. He encourages believers to seek understanding from the Holy Spirit about these passages, as they reveal God's plan for the end times and the importance of declaring His promises. Bickle explains that the remnant of Israel will be rescued and restored, and that the Gentiles will also come to know the Lord, culminating in a time of worship and praise. He stresses the need for the church to grasp these truths to effectively communicate God's storyline to the world.