J.R. Miller emphasizes the vital role of prayer in helping others, asserting that it is one of life's highest duties. He highlights that prayer is not just a wish but a powerful means of invoking God's help for those we care about, including friends and even enemies. Miller warns against the dangers of neglecting prayer, equating it to a sin against both our friends and God, and stresses that true love must include intercession for all, regardless of their treatment towards us. He encourages believers to pray for everyone, as prayer is a reflection of God's love and grace. Ultimately, Miller calls for a commitment to pray for others, especially those who may have wronged us, as a demonstration of Christ-like love.