J.C. Ryle emphasizes the necessity of prayer as a means to find happiness and contentment in a sorrowful world, where sin inevitably brings suffering. He encourages believers to cast their burdens on God, as prayer is the key to alleviating sorrow and finding peace amidst life's trials. Ryle illustrates how biblical figures turned to prayer in their times of distress, highlighting that Jesus is always ready to help those who seek Him. He warns those who do not pray of the dangers of remaining prayerless and urges them to approach God earnestly for salvation. Ultimately, Ryle reassures that true happiness is rooted in the state of the heart, not external circumstances.