David Wilkerson emphasizes the significance of family prayer, highlighting its power in fostering unity and spiritual strength within the home. He shares personal experiences of praying with his wife and the impact of family prayer during his childhood, illustrating how it can shape lives and relationships. Wilkerson encourages families to prioritize prayer, regardless of individual participation, as it can still create a spiritual atmosphere in the home. He stresses that even if some family members are reluctant, personal commitment to prayer can still influence the household positively.