David Wilkerson addresses the struggles of feeling abandoned by God during difficult times, using Jacob's wrestling with the Lord as a poignant example. He emphasizes that even the most faithful and contrite believers can face trials and sorrows, questioning God's presence and promises. Wilkerson reminds us that God does not guarantee a life free from afflictions, but rather assures us of His deliverance through them. He highlights that both Jacob and Paul experienced significant hardships, yet God was with them, ultimately bringing them through their struggles. The sermon encourages believers to trust in God's faithfulness, even when circumstances seem dire.