A.B. Simpson emphasizes that God often uses those who are despised and unpopular, reminding us that true recognition comes from God rather than man. He encourages believers to embrace their calling, even in the face of misunderstanding and prejudice, as many of God's greatest blessings lie beyond societal acceptance. Simpson asserts that the Holy Spirit is not ashamed to work through those who are marginalized, and that seeking God's will and glory should be our primary focus. He calls for courage to follow Christ, even when it means bearing reproach, assuring us that God will ultimately honor those who serve Him faithfully.