Andrew Murray emphasizes the profound truth that while salvation and living a holy life are impossible for man, they are entirely possible with God, as stated in Luke 18:27. He illustrates the journey of a believer from self-reliance and despair to recognizing their utter helplessness and the necessity of divine power to achieve a victorious Christian life. Murray encourages believers to embrace absolute surrender to God, acknowledging that it is through God's omnipotence that they can overcome sin and live in holiness. He calls on Christians to trust in God's ability to work in them, transforming their lives and enabling them to fulfill His will. Ultimately, the sermon is a reminder that with God, all things are possible, and believers should rely on His strength rather than their own.