C.H. Spurgeon emphasizes the profound assurance found in the promise 'God shall be with you,' as spoken by Jacob to Joseph. He reflects on the comfort that comes when loved ones depart, reminding us that God's presence remains with us, providing strength, safety, and companionship. Spurgeon encourages believers to find joy in the knowledge that God is with us in every aspect of our lives—individually, as families, and as churches. He highlights that with God by our side, we can face any challenge and that our endeavors will prosper under His guidance. Ultimately, the sermon calls for a hopeful and diligent spirit, celebrating the eternal presence of God among His people.