Chuck Smith emphasizes the transformative power of God's Word in cleansing our lives from guilt and sin. He explains that emotional disorders often stem from unresolved guilt, which can only be addressed through the acknowledgment of sin and the acceptance of God's forgiveness. By hiding God's Word in our hearts, we can find strength to resist sin and experience true cleansing. Smith reassures that while we may falter, God's grace allows us to start anew, highlighting the importance of immersing ourselves in Scripture for spiritual growth and freedom.