John Wesley expounds on Matthew 26, detailing the events leading to Jesus' crucifixion, including the Last Supper and Judas' betrayal. He emphasizes the significance of the Passover meal, where Jesus transforms the bread and wine into symbols of His body and blood, establishing a new covenant. Wesley highlights the disciples' struggles, particularly Peter's denial, and the profound sorrow Jesus experiences in Gethsemane. The sermon reflects on the divine plan unfolding through human actions, showcasing Jesus' calmness in the face of betrayal and suffering. Wesley encourages believers to recognize the depth of Christ's sacrifice and the importance of faithfulness amidst trials.