Chuck Smith emphasizes the importance of humility and the dangers of ambition in the lives of those God uses. He illustrates how Peter and John, after healing a lame man, redirected the people's admiration away from themselves and towards God, warning against the temptation to accept glory for God's work. Smith stresses that true servants of God must reckon their old nature as dead and avoid seeking personal fame or recognition, as this can lead to becoming unusable by God. He encourages believers to focus on glorifying God rather than themselves, highlighting the need for continual surrender to the Holy Spirit. The sermon serves as a reminder that God desires to use humble vessels who acknowledge His power and grace.