G.W. North preaches on the significance of the fifth seal in Revelation, emphasizing that while the devil appears to rule, it is ultimately God who is in control and overruling all events. He highlights the souls of the martyrs under the altar, who cry out for justice, and contrasts their desire for vengeance with the grace of God that offers forgiveness. North encourages believers to live righteously and to understand the power of the blood of Christ, which speaks better things than the blood of Abel, and to reflect on what their own lives and blood would testify before God.