Mike Bickle emphasizes the significance of the 'abomination of desolation' as a pivotal event in end-time prophecy, urging believers to take the teachings of Scripture literally rather than spiritualizing them. He highlights that this event, foretold by Daniel and referenced by Jesus in Matthew 24, marks the beginning of the great tribulation and requires a rebuilt temple in Jerusalem. Bickle explains that the abomination involves the Antichrist demanding worship through an image placed in the temple, leading to widespread persecution and desolation. He stresses the importance of understanding the implications of this prophecy for the future of the Church and the world, as it is central to recognizing the signs of the times.