John Gill emphasizes the prophetic warning in 2 Peter 3:3 about the emergence of scoffers in the last days who mock sin, religion, and the truths of Scripture. These individuals, driven by their own lusts, ridicule the teachings of the Gospel and the promises of God, including the second coming of Christ and the reality of judgment. Gill highlights that such scoffers have been foretold by the apostles and prophets, indicating that their presence is a sign of the times and a reminder of the urgency of faith. He calls believers to remain steadfast in their faith despite the derision they may face from the world. Ultimately, the sermon serves as a call to discernment and perseverance in the face of skepticism.