F.B. Meyer emphasizes that while it may seem counterintuitive for weary souls to find rest by taking on a yoke, Jesus invites us to share in His yoke, which He carries alongside us. This yoke is not a burden but a partnership, where Jesus, as our yokefellow, lightens our load and guides us through life's challenges. By accepting His invitation, we can find true rest for our souls as we work together with Him in the journey of life. Meyer illustrates this with the imagery of oxen working together in the fields, highlighting the importance of keeping in step with Jesus.