A.W. Tozer emphasizes that the first lesson a preacher must learn is the importance of prayer, which is often the most challenging task due to human weakness. He notes that while many aspects of ministry can be learned easily, true prayer requires deep personal struggle and cannot be imitated or learned from others. Tozer highlights the necessity of conquering one's own flesh to engage in effective prayer, as it is the primary hindrance to spiritual communication. He encourages a heartfelt commitment to prayer, seeking transformation through the Holy Spirit.