Zac Poonen emphasizes the necessity of the Holy Spirit's anointing in the life and ministry of Jesus, illustrating that Jesus went about doing good and healing those oppressed by the devil. He argues that just as Jesus needed the Spirit's anointing to fulfill His ministry, so do we, as members of the church, need this empowerment to effectively serve and minister to others. Poonen warns against a dry and lifeless ministry that lacks the Spirit's anointing, urging believers to seek and value this anointing to ensure their ministry is vibrant and impactful. He reminds us that Jesus continues His work through the church today, and we must not take our responsibility lightly, calling for repentance from self-sufficiency to embrace the Spirit's guidance.