John Wesley explains the genealogy of Jesus Christ as presented in Matthew 1, emphasizing its significance in establishing Jesus' rightful place as the Messiah from the lineage of David and Abraham. He notes that the genealogies serve to affirm the fulfillment of God's promises and the importance of Jesus' identity as both Savior and King. Wesley highlights the role of women in the genealogy and reflects on the nature of Christ as our mediator, prophet, and king, addressing our spiritual needs. He concludes with a reminder of the transient nature of human life and the eternal significance of being remembered by God.