John Wesley preaches on the limitations of human knowledge, emphasizing that while the desire for knowledge is innate and insatiable, our actual understanding is confined and often leads to pride. He reflects on the vastness of God's creation and the mysteries of His providence, highlighting that our knowledge is tailored to our current needs but remains woefully inadequate. Wesley urges listeners to embrace humility, faith, and resignation in the face of our ignorance, recognizing that true understanding comes from God alone. He concludes by encouraging a deep trust in God's wisdom and a willingness to submit to His will, as exemplified by Christ.