David Wilkerson emphasizes the transformative power of God's presence in the lives of believers, illustrating how figures like Moses and Abraham relied on God's assurance to navigate challenges. He highlights Moses' declaration that without God's presence, they would not move forward, showcasing the necessity of divine companionship. The sermon also recounts God's promises to Joshua and Isaiah, affirming that His presence empowers believers to conquer fears and face adversities. Ultimately, Wilkerson encourages the congregation to recognize and testify to the active presence of God in their lives, which sets them apart from nonbelievers.