George Muller emphasizes the importance of rising early to cultivate a deeper relationship with God through prayer and meditation. He shares his personal journey of overcoming the temptation to sleep in, which he found detrimental to both his physical and spiritual well-being. Muller encourages believers to prioritize their time with God, asserting that wasting time in bed is unbecoming for those redeemed by Christ. He advises that early rising, coupled with dependence on God's strength, leads to a more fulfilling and productive life. Ultimately, he calls on Christians to honor God by using their time wisely and to seek His help in establishing this habit.