John Wesley emphasizes the profound question posed by Jesus in Matthew 16:26, urging listeners to consider the futility of gaining worldly riches at the expense of their souls. He explores the implications of 'gaining the whole world'—pleasures, honors, and wealth—contrasting it with the devastating loss of one's soul, which leads to eternal separation from God. Wesley argues that true happiness is found in a life of love and faith, rather than in worldly pursuits, and he challenges his audience to make a conscious choice for eternal life over temporary gains. He concludes with a passionate call to choose life and adhere to that choice, promising a crown of righteousness for those who persevere in faith.