J.R. Miller discusses the shift in leadership from Barnabas to Paul during their missionary journey in Antioch, emphasizing Barnabas's humility and dedication to Christ's cause over personal ambition. Paul boldly shares the gospel in the synagogue, recounting the story of Jesus and urging the Jews to accept Him as the Messiah, but faces rejection and envy from some. The missionaries then turn to the Gentiles, who joyfully accept the message, highlighting the theme of acceptance and rejection of God's grace. Miller warns that rejecting Christ leads to deeper guilt and loss of blessings, while also reflecting on the nature of human opposition to God. The sermon concludes with a call to examine our own hearts and the effectiveness of our witness for Christ.