Andrew Murray emphasizes the profound privilege of entering the 'inner chamber' for prayer, as instructed by Jesus in Matthew 6:6. He encourages Christians to withdraw from worldly distractions and focus solely on the presence of God, assuring that sincere prayer will be rewarded. Murray highlights the importance of realizing God's presence, confessing sins, and bringing needs to the Father in the name of Christ. He reassures believers that their prayers are never in vain when offered in fellowship with Jesus. The sermon calls for a childlike trust in God during prayer.

"But thou, when thou prayest, enter into thy closet" - Matthew 6:6. Have you ever thought what a wonderful privilege it is that everyone, each day and each hour of the day, has the liberty of asking God to meet him in the inner chamber, and to hear what He has to say? We should hope and pray that every Christian uses such a privilege gladly and faithfully. "But thou, when thou prayest," says Jesus, "enter into thy closet, and when thou hast shut thy door, pray to thy Father which is in secret;" That means two things. Shut the world out, withdraw from all worldly thoughts and occupations, and shut yourself in alone with God, to pray to Him in secret. Let this be your chief object in prayer, to realize the presence of your heavenly Father. Focus on the words: Alone with God. This is only the beginning. I must take time to realize His presence with me, and pray to my Father who seeth in secret, in the full assurance that He knows how I long for His help and guidance, and will incline His ear to me. Then follows the great promise: "and thy Father which seeth in secret shall reward thee openly." My Father will see to it that my prayer is not in vain. All through the occupations of a busy day, the answer to my prayer will be granted. Prayer in secret will be followed by the secret working of God in my heart. As the Lord Jesus has given us the promise of His presence, and shows us the way to the inner chamber, He will assuredly be with us to teach us to pray. It is through Him that we have access to the Father. Be childlike and trustful in your fellowship with Christ. Confess each sin, bring your every need. Offer your prayer to the Father in the name of Christ. Prayer in fellowship with Jesus cannot be in vain.