This sermon emphasizes the importance of responding properly to God's call, highlighting the consequences of improper responses seen in various biblical examples. It discusses the need to seek, inquire, obey, trust, and draw near to God in a way that aligns with His will, contrasting it with the dangers of disobedience, lack of correction, and failure to seek the Lord. The message urges a shift from improper responses to a proper, humble, and repentant attitude before God.

C.H. Spurgeon emphasizes the destructive nature of blight, mildew, and hail as divine chastisements that can ruin the fruits of our labor, both physically and spiritually. He illustrates how these forces, beyond human control, remind us of our dependence on God's mercy and the necessity of prayer for daily sustenance. Spurgeon warns that spiritual mildew can hinder our efforts in ministry, leading to apathy and worldliness, and calls for vigilance against spiritual pride and sloth. Ultimately, he urges believers to seek God's intervention to protect their hearts and work from these destructive forces.