Mike Bickle emphasizes the incredible worth of women, particularly mothers, in his Mother's Day sermon. He highlights that honoring women is foundational to the church's glory and the effectiveness of prayer, as dishonoring women can hinder one's relationship with God. Bickle encourages men to see and affirm the virtues in women, treating them with purity and respect, and to understand that their role is to uplift and cherish their wives. He connects this honor to the broader context of the church's mission and the end-time revival, asserting that the acknowledgment of women's worth is crucial for spiritual growth and community health.