F.B. Meyer emphasizes God's call to Abraham to 'walk before Me, and be thou perfect,' highlighting the importance of whole-hearted devotion to God. He reflects on the long silence Abraham experienced, which tested his faith and reliance on God's promises. Meyer clarifies that perfection does not equate to sinlessness but rather to a complete surrender and commitment to God. He encourages believers to seek a life of undivided devotion, trusting in the Almighty God who empowers them to fulfill His calling. Ultimately, the sermon calls for a deep, personal relationship with God, where His presence guides every aspect of life.